The offered suspension is processed by pharmaceutical experts who use best quality chemicals & leading edge technology for processing. Co-Trimoxazole 40 mg/200 mg per 5 ml Paediatric Suspension - Patient Information Leaflet (PIL) - (emc) derivatives; ATC code: J01EE01. * see description of selected adverse reactions, Description of selected adverse reactions. Severe hypersensitivity reactions have been reported in PJP patients on re-exposure to co-trimoxazole, sometimes after a dosage interval of a few days. At doses in excess of recommended human therapeutic dose, trimethoprim and sulfamethoxazole have been reported to cause cleft palate and other foetal abnormalities in rats, findings typical of a folate antagonist. Contraindicated in patients with anemia, hypersensitivity, during pregnancy and breast-feeding. Manufacturer of a wide range of products which include codoz ( co -trimoxazole oral suspension bp), metronidazole oral suspension bp, nystatin oral suspension bp 1,00,000 iu, ciprofloxacin 250 mg suspension, amoxicillin oral suspension bp 250 mg and cefixime for oral suspension usp 100 mg/5 ml. Co-Trimoxazole Paediatric Suspension is indicated in children aged 12 years and under (infants (>6 weeks to <2 years old) and children (>2 to <12 years old) for the treatment of the following infections when owing to sensitive organisms (see section 5.1): • Treatment and prevention of Pneumocystis jirovecii pneumonitis (PJP). 5.Bygbjerg IC, Lund JT, Hording M. Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. The principal route of excretion of trimethoprim is renal and approximately 50% of the dose is excreted in the urine within 24 hours as unchanged drug. Measurements of plasma concentration of sulfamethoxazole at intervals of 2 to 3 days are recommended in samples obtained 12 hours after administration of Co-Trimoxazole. The daily dose given on a treatment day approximates to 150 mg trimethoprim/m2/day and 750 mg sulfamethoxazole/m2/day. This information gives only an approximate guidance on probabilities whether microorganisms will be susceptible to trimethoprim/sulfamethoxazole or not. It should only be considered for use in acute exacerbations of chronic bronchitis and infections of the urinary … When trimethoprim is administered simultaneously with drugs that form cations at physiological pH, and are also partly excreted by active renal secretion (e.g. It usually is taken two times a day but may be taken up to four times a day when used to treat certain severe lung infections. Bacterial mutations cause an increase the concentration of PABA and thereby out- compete with sulfamethoxazole resulting in a reduction of the inhibitory effect on dihydropteroate synthetase enzyme. Effective levels persist in the blood for up to 24 hours after a therapeutic dose. Serum sickness, anaphylactic reaction, allergic myocarditis, hypersensitivity vasculitis resembling Henoch-Schoenlein purpura, periarteritis nodosa, systemic lupus erythematosus. Sulfamethoxazole may displace warfarin from plasma-albumin protein-binding sites in vitro. Tablets – swallow the tablets with a glass of water. Musculoskeletal and connective tissue disorders. Trimethoprim binds to plasmodial DHFR but less tightly than to the bacterial enzyme. Further a detrimental effect on such activities cannot be predicted from the pharmacology of the drug. Co-Trimoxazole Paediatric Suspension is indicated in children aged 12 years and under (infants (>6 weeks to <2 years old) and children (>2 to <12 years old) for the treatment of the following infections when owing to sensitive organisms (see section 5.1): • Treatment and prevention of Pneumocystis jirovecii pneumonitis (PJP). Pharmacotherapeutic group: Combinations of sulfonamides and trimethoprim, incl. Consideration should be given to official guidance on the appropriate use of antibacterial agents. If vomiting has not occurred, induction of vomiting may be desirable. Some of the dosage forms listed on this page may not apply to the brand name Co-trimoxazole.. For the Consumer. As an alternative to Standard Dosage for acute uncomplicated lower urinary tract infections, short-term therapy of 1 to 3 days duration has been shown to be effective. … Savorite Pharmaceuticals - Offering Co Trimoxazole Oral Suspension, ओरल सस्पेंशन, Oral Suspensions in Sarabhai Compound, Vadodara, Gujarat. In addition, adverse events may vary in their incidence depending on the indication. Jaundice cholestatic and hepatic necrosis may be fatal. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. The pharmacokinetics in the paediatric population with normal renal function of both components of Co-Trimoxazole, TMP and SMZ are age dependent. As significantly maternally derived drug levels persist for several days in the newborn, there may be a risk of precipitating or exacerbating neonatal hyperbilirubinaemia, with an associated theoretical risk of kernicterus, when Co-Trimoxazole is administered to the mother near the time of delivery. Hypersensitivity to the active substance(s) sulphonamides, trimethoprim, co-trimoxazole or to any of the excipients listed in section 6.1. This may not be the case in gross overdosage. Die Standarddosis für Erwachsene beträgt in der Regel 2 –mal täglich 960 mg pro Tag (jeweils 800mg Sulfamethoxazol und 160mg Trimethoprim). Respiratory, thoracic and mediastinal disorders, Jaundice cholestatic *, hepatic necrosis*. Sulfamethoxazole competitively inhibits the utilisation of para-aminobenzoic acid in the synthesis of dihydrofolate by the bacterial cell resulting in bacteriostasis. • If symptoms or signs of SJS or TEN (e.g. Trimethoprim-sulfamethoxazole ( co-trimoxazole): Class: Antibiotic. Contraceptives: oral contraceptive failures have been reported with antibiotics. It's sometimes given by drip into a vein for more severe infections. Close monitoring of the patient's condition and serum phenytoin levels are advisable. Nevertheless the clinical status of the patient and the adverse events profile of Co-Trimoxazole should be borne in mind when considering the patients ability to operate machinery. Co trimoxazole Paediatric Suspension is used to treat certain infections such as urinary tract infections, middle ear infection (acute otitis media) in children, intestinal infection (shigellosis), serious lung infection in people with the weakened immune system (pneumocystis carinii pneumonia), infection of the digestive tract (traveler's diarrhea in adults). It is increased by a factor of 1.5 to 3.0 when the creatinine clearance is less than 10 ml/minute. Das Reaktionsvermögen kann auch bei bestimmungsgemäßem Gebrauch, vor allem in höheren Dosierungen oder in Kombination mit Alkohol, beeinträchtigt sein. Transaminases increased, blood bilirubin increased. Trimethoprim is a folate antagonist and, in animal studies, both agents have been shown to cause foetal abnormalities (see section 5.3). Folate supplementation should be considered if Co-Trimoxazole is used in pregnancy. Write your Answer here... Director of Women's Health, SHEROES What is your question? DEV LIFE CORPORATION . Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. Looking for ideal Co-trimoxazole Oral 240mg/5ml Manufacturer & supplier ? Trimethoprim in Oral Suspension by Classical Least Square Calibration Method. Pyrimethamine: occasional reports suggest that patients receiving pyrimethamine at doses in excess of 25 mg weekly may develop megaloblastic anaemia should co-trimoxazole be prescribed concurrently. There is no consensus on the most appropriate dosage. 2. Active substance(s): SULFAMETHOXAZOLE / TRIMETHOPRIM, PDF options:  View Fullscreen   Download PDF. Although it has been prescribed widely for a range of infections in the past, it has very occasionally been associated with some serious side-effects. This action produces marked potentiation of activity in vitro between the two agents. Repaglinide: trimethoprim may increase the exposure of repaglinide which may result in hypoglycaemia. Interaction with sulphonylurea hypoglycaemic agents is uncommon but potentiation has been reported. It may be preferable to take Co-Trimoxazole with some food or drink to minimise the possibility of gastrointestinal disturbances. At the high dosages used for PJP management severe hypersensitivity reactions have been reported, necessitating cessation of therapy. • Patients should be advised of the signs and symptoms and monitored closely for skin reactions. • Treatment and prophylaxis of toxoplasmosis. Diuretics (thiazides): in older patients concurrently receiving diuretics, mainly thiazides, there appears to be an increased risk of thrombocytopenia with or without purpura. Pregnant women has not occurred, induction of vomiting may be useful though. 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